Acid reflux is a common condition in the West and there is a suggestion
that it is increasing. Obesity is increasing in the West and since
obesity can cause or worsen acid reflux, the increase in acid reflux
is likely to be related to a combination of our diet, lifestyle
and obesity. There is, however, a group that develops acid reflux
as a part of life's natural process. Pregnant women develop GERD
symptoms as a result of pregnancy.
It is estimated that as much as 80% of pregnant
women have GERD symptoms and the symptoms vary from mild to very
severe. It is rarely serious in this group and, of course, it is
limited to the length of the pregnancy.
Nausea and vomiting is common in the first trimester
and is mainly due to the rising level of the female hormone, estrogen
and progesterone circulating in the blood stream. Acid reflux symptoms
are more common in the third trimester.
In the third trimester, the uterus is large and
has pushed up into the upper abdomen distorting the configuration
of the organs in the abdomen. The stomach is pushed up against the
diaphragm. This can affect the competence of the Lower Esophageal
Sphincter (LES) and cause acid reflux. It can also force part of
the stomach up through the diaphragmatic hiatus. This is a hiatus
hernia. A hiatus hernia can result in acid reflux.
In addition weight gain during pregnancy (especially
in the apple shape) will settle around the waist. This weight will
press on the abdomen and increase the intra-abdominal pressure.
This pressure on the LES may force food up into the esophagus.
During pregnancy estrogen and progesterone levels
need to be high to maintain the pregnancy. These two female hormones
are produced by the ovaries until the placenta takes over. These
hormones relax smooth muscles of the uterus and are necessary to
allow the uterus to stretch to accommodate the developing pregnancy.
Unfortunately this muscle relaxation is not confined
to the uterus. The muscles of the GI tract are affected. In the
large bowel reduced strength of peristaltic contraction leads to
slow transit time and likely constipation. In the esophagus it reduces
the tone of the LES allowing reflux and slows down peristalsis along
the esophagus. The food swallowed is cleared slower and the LES
is lax. A double whammy.
Patients who have had GERD symptoms before falling
pregnant tend to have severe GERD in pregnancy. Sometimes in pregnancy
GERD can be so severe that hospitalisation is necessary. Also vomiting
can be so severe that weight loss follows. In pregnancy regular
weight gain is expected. Weight loss suggests a referral to a gastro-enterologist
especially if the weight is below the pre-pregnancy benchmark.
Severe GERD can lead to mal-nutrition. This can
be harmful to the mother and may put the foetus at risk at a time
of vital development and growth.
Ginger is a good safe treatment of GERD in pregnancy
and you only need a small amount. It can stimulate saliva production.
Saliva is a natural antacid. Ginger helps relieve nausea and vomiting
and it is a carminative (relieve gas). Lifestyle change is important.
If still smoking and drinking alcohol, then it is time to stop.
Elevating the head of the bed is beneficial and lying on the left
side is best because in this position the stomach is lower than
the esophagus.
Avoid or reduce your intake of fats, coffee, tea,
chocolate, certain citrus fruits, certain spices, tomatoes and garlic.
When exercising, avoid bouncing up and down and exercises that involve
bending forwards. Stick to exercises that keep you upright. Stretching
exercises and power or brisk walking are unlikely to aggravate GERD
symptoms.
Antacids are safe in pregnancy because they do not
cross the placenta into the baby's circulation. However, antacids
containing sodium (sodium bicarbonate) can cause fluid retention.
Aluminium containing antacids can make constipation of pregnancy
worse. Magnesium can slow down labour. These drugs are in Category
A. The categories were laid down by the FDA in 1979 and are related
to safety profile and potential harm to the foetus. Category A is
safe in pregnancy.
The H2-receptor antagonists and proton pump inhibitors
are in Category B except omeprazole which is in Category C. These
drugs cross the placenta but trials results are not adequate to
consider them safe during pregnancy. So far no trial has shown any
harm to the foetus.